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Los Angeles (CNN) — Jurors in the involuntary manslaughter trial of Michael Jackson’s doctor will hear closing arguments from the prosecution and defense Thursday, with deliberations on Dr. Conrad Murray’s fate expected to begin late Thursday or Friday.

It follows 22 days of testimony from several of Murray’s girlfriends and patients, Jackson employees, paramedics and emergency room doctors, investigators and medical experts.

Jackson’s mother will sit on one side of the courtroom, while Murray’s mother is likely to be seated on the other end Thursday as the seven men and five women on the jury listen to each side sum up their case.

Jackson was preparing for a series of 50 shows in London, part of a career comeback, when he died on June 25, 2009.

Murray told detectives in an interview two days after Jackson’s death that he had used the surgical anesthetic propofol to help Jackson sleep nearly every night for the previous two months, with the exception of his last three nights.

He was using the sedatives lorazepam and Midazolam in an effort to wean Jackson off of propofol the morning he died, Murray said. When those drugs weren’t working after almost 10 hours of trying, he gave him a single injection of propofol, which did put Jackson to sleep, he said.

Jackson’s death was caused by “acute propofol intoxication” in combination with two sedatives, the Los Angeles County coroner ruled.

The prosecution contends Dr. Murray’s use of propofol to treat Jackson’s insomnia was so reckless it was criminally negligent and caused the singer’s death.

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